Timeline

•1993: studies showing biV pacing improved functional capacity-standard RV pacing leads 1st used for CS branches
•1999: left free wall best place for LV leads (PATCH-CHF)
•2001: 1st trial showing clinical benefits of CRT (MUSTIC)
•2002: Medtronic created CS shaped leads-2187, 2188
•2002: LV+40ms most beneficial
•2004: 1st trial show improvement of endpoint – HF hospitilisation and/or death(COMPANION)
•2005: 1st trial show mortality benefit of CRTP (CARE-HF)
•2009: inclusion category expanded – NYHA I & II (mild HF) improvement (MADIT CRT)